Article
Modulation of renin angiotensin system predominantly alters sclerotic phenotype of glomeruli in HIVAN.
Histology and histopathology - 1 Dec 2014
Plagov Andrei, Lan Xiqian, Rai Partab, Kumar Dileep, Lederman Rivka, Rehman Shabina, Malhotra Ashwani, Ding Guohua, Chander Praveen N, Singhal Pravin C
Abstract excerpt
HIV-associated nephropathy (HIVAN) is a common complication of HIV-1 infection in patients with African ancestry in general and with APOL1 gene risk variants in particular. Although collapsing glomerulopathy is considered a hallmark of HIVAN, significant numbers of glomeruli in patients with HIVAN also display other variants of focal segmental glomerulosclerosis (FSGS). We propose that collapsed glomeruli as well...
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