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Article

HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN.

AIDS (London, England) - 18 Nov 2005

Husain Mohammad, D'Agati Vivette D, He John Cijiang, Klotman Mary E, Klotman Paul E

Abstract excerpt

OBJECTIVE: To determine the specific role of Nef in the pathogenesis of HIV-associated nephropathy. DESIGN: Podocytes are highly differentiated non-dividing cells in the normal glomerulus, however, they undergo dedifferentiation and acquire a proliferative phenotype in HIVAN patients, in HIV-transgenic mice and if infected by HIV-1 in vitro. These changes are accompanied by loss of the maturation markers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16260903
DOI: 10.1097/01.aids.0000191918.42110.27

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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