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Article

Identification of the nephropathy-susceptibility locus HIVAN4.

Journal of the American Society of Nephrology : JASN - 1 Aug 2011

Prakash Sindhuri, Papeta Natalia, Sterken Roel, Zheng Zongyu, Thomas Robert L, Wu Zhenzhen, Sedor John R, D'Agati Vivette D, Bruggeman Leslie A, Gharavi Ali G

Abstract excerpt

HIVAN1, HIVAN2, and HIVAN3 are nephropathy-susceptibility loci previously identified in the HIV-1 transgenic mouse, a model of collapsing glomerulopathy. The HIVAN1 and HIVAN2 loci modulate expression of Nphs2, which encodes podocin and several other podocyte-expressed genes. To identify additional loci predisposing to nephropathy, we performed a genome-wide scan in 165 backcross mice generated between the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21784893
DOI: 10.1681/ASN.2011020209
PMCID: PMC3148704

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