Article
Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease.
Journal of virology - 1 Jan 1998
Hanna Z, Kay D G, Cool M, Jothy S, Rebai N, Jolicoeur P
Abstract excerpt
We have constructed transgenic (Tg) mice expressing the entire human immunodeficiency virus type 1 (HIV-1) coding sequences in cells targeted by HIV-1 infection in humans. These Tg mice developed a severe AIDS-like disease leading to early death (< 1 month). They developed muscle wasting, severe...
Topics
- Acquired Immunodeficiency Syndrome
- Animals
- Base Sequence
- CD4 Antigens
- Chemokine CCL5
- DNA Primers
- Disease Models, Animal
- Female
- Gene Expression
- Genome, Viral
- HIV-1
- Humans
- Immune System
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Transgenic