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Article

Dynamics of the rhomboid-like protein RHBDD2 expression in mouse retina and involvement of its human ortholog in retinitis pigmentosa.

The Journal of biological chemistry - 5 Apr 2013

Ahmedli Novruz B, Gribanova Yekaterina, Njoku Collins C, Naidu Akash, Young Alejandra, Mendoza Emmanuel, Yamashita Clyde K, Özgül Riza Köksal, Johnson Jerry E, Fox Donald A, Farber Debora B

Abstract excerpt

The novel rhomboid-like protein RHBDD2 is distantly related to rhomboid proteins, a group of highly specialized membrane-bound proteases that catalyze regulated intramembrane proteolysis. In retina, RHBDD2 is expressed from embryonic stages to adulthood, and its levels show age-dependent changes. RHBDD2 is distinctly abundant in the perinuclear region of cells, and it localizes to their Golgi. A glycine zipper...

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Source

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Identifiers

PMID: 23386608
DOI: 10.1074/jbc.M112.419960
PMCID: PMC3617276

Genes

RHBDD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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