Article
An intramembrane glutamic acid governs peripherin/rds function for photoreceptor disk morphogenesis.
Investigative ophthalmology & visual science - 1 Jul 2007
Goldberg Andrew F X, Ritter Linda M, Khattree Nidhi, Peachey Neal S, Fariss Robert N, Dang Loan, Yu Minzhong, Bottrell Alyssa R
Abstract excerpt
PURPOSE: Peripherin/rds (P/rds), the product of the retinal degeneration slow (rds) gene, is a tetraspanin protein that plays a pivotal role for photoreceptor outer segment (OS) structure and is involved in a broad spectrum of inherited retinal degenerations. P/rds interacts with the homologous protein rom-1, previously proposed to regulate P/rds function. The authors examined the significance of an intramembrane...
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