Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Interplay between Peripherin 2 Complex Formation and Degenerative Retinal Diseases.

Cells - 24 Mar 2020

Tebbe Lars, Kakakhel Mashal, Makia Mustafa S, Al-Ubaidi Muayyad R, Naash Muna I

Abstract excerpt

Peripherin 2 (Prph2) is a photoreceptor-specific tetraspanin protein present in the outer segment (OS) rims of rod and cone photoreceptors. It shares many common features with other tetraspanins, including a large intradiscal loop which contains several cysteines. This loop enables Prph2 to associate with itself to form homo-oligomers or with its homologue, rod outer segment membrane protein 1 (Rom1) to form...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular transport and secretion
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Therapy

Share to Morphogenesis

Share to Mutation

Share to Peripherins

Share to Retinal Degeneration

Share to Retinal Development and Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 32213850
DOI: 10.3390/cells9030784
PMCID: PMC7140794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Interplay between Peripherin 2 Complex Formation and Degenerative Retinal Diseases.PMID 32213850Read ↗

Oligomerization of Prph2 and Rom1 is essential for photoreceptor outer segment formation.Semantic proximity Read ↗

PRPH2/RDS and ROM-1: Historical context, current views and future considerations.Semantic proximity Read ↗

A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration.Semantic proximity Read ↗

The Role of Peripherin-2/ROM1 Complexes in Photoreceptor Outer Segment Disc Morphogenesis.Semantic proximity Read ↗

Prph2 initiates outer segment morphogenesis but maturation requires Prph2/Rom1 oligomerization.Semantic proximity Read ↗

ROM1 contributes to phenotypic heterogeneity in PRPH2-associated retinal disease.Semantic proximity Read ↗

Rom1 converts Y141C-Prph2-associated pattern dystrophy to retinitis pigmentosa.Semantic proximity Read ↗

Comparative study of PRPH2 D2 loop mutants reveals divergent disease mechanism in rods and cones.Semantic proximity Read ↗

ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims.Semantic proximity Read ↗

Photoreceptor Disc Enclosure Is Tightly Controlled by Peripherin-2 Oligomerization.Semantic proximity Read ↗

Delineating the Clinical Phenotype of Patients With the c.629C>G, p.Pro210Arg Mutation in Peripherin-2.Semantic proximity Read ↗

Prph2 disease mutations lead to structural and functional defects in the RPE.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.