Article
Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.
The Journal of biological chemistry - 24 Oct 2014
Patil Hemangi, Saha Arjun, Senda Eugene, Cho Kyoung-in, Haque MdEmdadul, Yu Minzhong, Qiu Sunny, Yoon Dosuk, Hao Ying, Peachey Neal S, Ferreira Paulo A
Abstract excerpt
Retinal pigment epithelium (RPE) degeneration underpins diseases triggered by disparate genetic lesions, noxious insults, or both. The pleiotropic Ranbp2 controls the expression of intrinsic and extrinsic pathological stressors impinging on cellular viability. However, the physiological targets and mechanisms controlled by Ranbp2 in tissue homeostasis, such as RPE, are ill defined. We show that mice,...
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