Article
NAALAD2 mutations disrupt the fate of photoreceptor cells and retinal pigment epithelial cells during early retinal development.
Pharmacological research - 1 May 2025
Qian Yuanjie, Gao Jian, Zhang Zheming, Chen Yixuan, Su Jindi, Niu Xing, Zheng Kaifeng, Bao Yantao, Qin Yueyuan, Zheng Junge, Yang Yuankai, Wu Qunyan, Mo Ke, Wei Yantao, Duan Shan
Abstract excerpt
In recent years, the global incidence of myopia has steadily increased, highlighting the importance of prevention and early intervention, particularly in the absence of effective treatments. Here, we identified a previously unreported mutation in the human N-acetylated alpha-linked acidic dipeptidase 2 (NAALAD2) gene (c.2109 T > G, p.F703L) considered in a Chinese family with pathological myopia (PM). We explored...
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