Article
Prph2 initiates outer segment morphogenesis but maturation requires Prph2/Rom1 oligomerization.
Human molecular genetics - 1 Feb 2019
Conley Shannon M, Stuck Michael W, Watson Jamie N, Zulliger Rahel, Burnett Justin L, Naash Muna I
Abstract excerpt
The retinal disease gene peripherin 2 (PRPH2) is essential for the formation of photoreceptor outer segments (OSs), where it functions in oligomers with and without its homologue ROM1. However, the precise role of these proteins in OS morphogenesis is not understood. By utilizing a knock-in mouse expressing a chimeric protein comprised of the body of Rom1 and the C-terminus of Prph2 (termed RRCT), we find that...
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