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APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians.

Experimental gerontology - 1 Apr 2013

Golanska Ewa, Sieruta Monika, Gresner Sylwia M, Pfeffer Anna, Chodakowska-Zebrowska Malgorzata, Sobow Tomasz M, Klich Izabela, Mossakowska Malgorzata, Szybinska Aleksandra, Barcikowska Maria, Liberski Pawel P

Abstract excerpt

APBB2 gene encodes for β-amyloid precursor protein-binding family B member 2, (APBB2, FE65-like, FE65L1), an adaptor protein binding to the cytoplasmatic domain of β-amyloid precursor protein (βAPP). Over-expression of APBB2 promotes formation of β-amyloid (Aβ), the main constituent of senile plaques. Polymorphisms within APBB2 gene have been proposed as candidate risk factors for Alzheimer's disease. However,...

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Identifiers

PMID: 23384821
DOI: 10.1016/j.exger.2013.01.013

Genes

APBB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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