Investigating the Impact of ABCB1 3435C>T (rs1045642) Variant on Severity and Cognitive Decline in Egyptian Alzheimer's Disease Patients.

doi:10.1007/s12035-026-05789-w

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Investigating the Impact of ABCB1 3435C>T (rs1045642) Variant on Severity and Cognitive Decline in Egyptian Alzheimer's Disease Patients.

Molecular neurobiology - 26 Mar 2026

Farouk Yasmeen K, Nagy Nahla Elsayed, El Amir Azza M, Madbouly Neveen Adel, El-Khazragy Nashwa

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a complex genetic risk. The ABCB1 gene encodes P-glycoprotein, a blood-brain barrier efflux transporter involved in amyloid-β (Aβ) clearance. Variants in ABCB1 3435C>T (rs1045642) may influence AD susceptibility and severity, but data from Middle Eastern populations remain limited. The objective of the study is to investigate the ABCB1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to ATP Binding Cassette Transporter, Subfamily B

Share to Case-Control Studies

Share to Cognitive Dysfunction

Share to Egypt

Share to Gene Frequency

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 41882463
DOI: 10.1007/s12035-026-05789-w
PMCID: PMC13018025

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating the Impact of ABCB1 3435C>T (rs1045642) Variant on Severity and Cognitive Decline in Egyptian Alzheimer's Disease Patients.PMID 41882463Read ↗

Association between ABCB1 polymorphisms and haplotypes and Alzheimer's disease: a meta-analysis.Semantic proximity Read ↗

ABCB1 C3435T polymorphism influences the risk for Alzheimer's disease.Semantic proximity Read ↗

ABCB1 Gene Polymorphisms and Their Contribution to Cognitive Decline in Mild Cognitive Impairment: A Next-Generation Sequencing Study.Semantic proximity Read ↗

The role of ATP-binding cassette subfamily A in the etiology of Alzheimer’s diseaseSemantic proximity Read ↗

Alzheimer's Disease and Effects of ABCA7 Polymorphisms: A Review.Semantic proximity Read ↗

The impact of ABCB1 gene polymorphism (C3435T) and its expression on response to Donepezil in Moroccan patients with Alzheimer's diseaseSemantic proximity Read ↗

Alzheimer's disease in the Kingdom of Saudi Arabia: Current perspectives and genetic insights.Semantic proximity Read ↗

Apolipoprotein E (APOE) and Alzheimer's disease risk in a Ugandan population: A pilot case-control study.Semantic proximity Read ↗

Analyzing large-scale samples confirms the association between the ABCA7 rs3764650 polymorphism and Alzheimer's disease susceptibility.Semantic proximity Read ↗

ATP binding cassette subfamily A member 7 rs3764650 polymorphism and the risk of Alzheimer's disease.Semantic proximity Read ↗

Association between the ABCG2 C421A polymorphism and Alzheimer's disease.Semantic proximity Read ↗

ABC Transporters, APOE, CYP46A1 and LRP1 Gene Polymorphisms as Markers of Dementia Development in Patients with HyperlipidemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.