Article
Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease.
Human mutation - 1 Mar 2005
Li Yonghong, Hollingworth Paul, Moore Pamela, Foy Catherine, Archer Nicola, Powell John, Nowotny Petra, Holmans Peter, O'Donovan Michael, Tacey Kristina, Doil Lisa, van Luchene Ryan, Garcia Veronica, Rowland Charles, Lau Kit, Cantanese Joseph, Sninsky John, Hardy John, Thal Leon, Morris John C, Goate Alison, Lovestone Simon, Owen Michael, Williams Julie, Grupe Andrew
Abstract excerpt
Alzheimer disease (AD) is a complex neurodegenerative disorder predisposed by multiple genetic factors. Mutations in amyloid beta precursor protein (APP) are known to be associated with autosomal dominant, early onset familial AD and possibly also late onset AD (LOAD). A number of genes encoding...
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