Article
A risk for early-onset Alzheimer's disease associated with the APBB1 gene (FE65) intron 13 polymorphism.
Neuroscience letters - 15 May 2003
Cousin Emmanuelle, Hannequin Didier, Ricard Sylvain, Macé Sandrine, Génin Emmanuelle, Chansac Céline, Brice Alexis, Dubois Bruno, Frebourg Thierry, Mercken Luc, Benavides Jesus, Pradier Laurent, Campion Dominique, Deleuze Jean François
Abstract excerpt
Alzheimer's disease (AD) is a genetically complex neurodegenerative disorder and the leading cause of dementia of the elderly. Recently, Hu et al. suggested that a trinucleotide deletion in intron 13 of the APBB1 gene was a factor protecting against late-onset AD. We report here the results of a case/control study aimed at replicating this association. Our study included 461 AD patients and 397 matched controls....
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