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Article

Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients.

Neuroscience letters - 15 Dec 2000

Guénette S Y, Bertram L, Crystal A, Bakondi B, Hyman B T, Rebeck G W, Tanzi R E, Blacker D

Abstract excerpt

A genetic polymorphism in intron 13 of the FE65 gene (APBB1) was reported to be associated with Alzheimer's disease (AD). Our analyses of this polymorphism, both in a family-based or a case-control sample, fail to support the association between the FE65 intron 13 polymorphism and AD. We performed the sibship disequilibrium test (SDT, P=0.77) and the sib transmission/disequilibrium test (Sib-TDT, P=0.56) in a...

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Source

Identifiers

PMID: 11099823
DOI: 10.1016/s0304-3940(00)01607-4

Genes

APBB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients.PMID 11099823Read ↗

A risk for early-onset Alzheimer's disease associated with the APBB1 gene (FE65) intron 13 polymorphism.Semantic proximity Read ↗

Analysis of APBB2 gene polymorphisms in sporadic Alzheimer's disease.Semantic proximity Read ↗

No association between an intronic biallelic polymorphism of the FE65 gene and Alzheimer's disease.Semantic proximity Read ↗

A candidate molecular mechanism for the association of an intronic polymorphism of FE65 with resistance to very late onset dementia of the Alzheimer type.Semantic proximity Read ↗

Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies.Semantic proximity Read ↗

APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians.Semantic proximity Read ↗

A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains.Semantic proximity Read ↗

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