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Article

Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Aug 2006

Coon Keith D, Siegel Andrew M, Yee Stephanie J, Dunckley Travis L, Mueller Claudius, Nagra Rashed M, Tourtellotte Wallace W, Reiman Eric M, Papassotiropoulos Andreas, Petersen Floyd F, Stephan Dietrich A, Kirsch Wolff M

Abstract excerpt

The role of iron metabolism in Alzheimer's disease (AD) is well documented. Regulation of the proteins that maintain cellular iron metabolism is mediated by two cytoplasmic RNA-binding proteins, the Iron Regulatory Proteins (IRP1 and IRP2), that function through post-transcriptional interactions with RNA stem loop structures called iron-responsive elements. As the primary mediator of iron homeostasis in neuronal...

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Identifiers

PMID: 16914832
DOI: 10.3233/jad-2006-9301
PMCID: PMC1555623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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