Article
ABCB1 Gene Polymorphisms and Their Contribution to Cognitive Decline in Mild Cognitive Impairment: A Next-Generation Sequencing Study.
The journals of gerontology. Series A, Biological sciences and medical sciences - 5 May 2025
Šerý Omar, Sheardová Kateřina, Dziedzinska Radka, Zeman Tomáš, Vyhnálek Martin, Marková Hana, Laczó Jan, Lochman Jan, Vrzalová Kamila, Balcar Vladimir J, Hort Jakub
Abstract excerpt
The ABCB1 gene, encoding the ATP-dependent translocase ABCB1, plays a crucial role in the clearance of amyloid-beta (Aβ) peptides and the transport of cholesterol, implicating it in the pathogenesis of Alzheimer's disease. The study aims to investigate the association between polymorphisms in the ABCB1 gene and cognitive decline in individuals with mild cognitive impairment (MCI), particularly focusing on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.