Article
Germline allele-specific expression of DAPK1 in chronic lymphocytic leukemia.
PloS one - 1 Jan 2013
Wei Quan-Xiang, Claus Rainer, Hielscher Thomas, Mertens Daniel, Raval Aparna, Oakes Christopher C, Tanner Stephan M, de la Chapelle Albert, Byrd John C, Stilgenbauer Stephan, Plass Christoph
Abstract excerpt
We previously reported a rare germline variant (c.1-6531) that resulted in allele-specific expression (ASE) of death-associated protein kinase 1 (DAPK1) and predisposition to chronic lymphocytic leukemia (CLL). We investigated a cohort of CLL patients lacking this mutation for the presence of ASE of DAPK1. We developed a novel strategy that combines single-nucleotide primer extension (SNuPE) with MALDI-TOF mass...
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