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Quantitative analyses of DAPK1 methylation in AML and MDS

14 Sept 2011

Abstract excerpt

Aberrant DNA methylation and concomitant transcriptional silencing of death-associated protein kinase 1 (DAPK1) have been demonstrated to be key pathogenic events in chronic lymphocytic leukemia (CLL). In acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), however, the presence of elevated DNA methylation levels has been a matter of continued controversy. Several studies demonstrated highly variable...

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PMID: 21918973
DOI: 10.1002/ijc.26429

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