DAPK1 variants are associated with Alzheimer's disease and allele-specific expression.

doi:10.1093/hmg/ddl178

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Article

DAPK1 variants are associated with Alzheimer's disease and allele-specific expression.

Human molecular genetics - 1 Sept 2006

Li Yonghong, Grupe Andrew, Rowland Charles, Nowotny Petra, Kauwe John S K, Smemo Scott, Hinrichs Anthony, Tacey Kristina, Toombs Timothy A, Kwok Shirley, Catanese Joseph, White Thomas J, Maxwell Taylor J, Hollingworth Paul, Abraham Richard, Rubinsztein David C, Brayne Carol, Wavrant-De Vrièze Fabienne, Hardy John, O'Donovan Michael, Lovestone Simon, Morris John C, Thal Leon J, Owen Michael, Williams Julie, Goate Alison

Abstract excerpt

Genetic factors play an important role in the etiology of late-onset Alzheimer's disease (LOAD). We tested gene-centric single nucleotide polymorphisms (SNPs) on chromosome 9 and identified two SNPs in the death-associated protein kinase, DAPK1, that show significant association with LOAD. SNP rs4878104 was significantly associated with LOAD in our discovery case-control sample set (WU) and replicated in each of...

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PMID: 16847012
DOI: 10.1093/hmg/ddl178

Genes

DAPK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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