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Article

Aberrant methylation of the death‐associated protein kinase 1 (<i>DAPK1</i>) CpG island in chronic myeloid leukemia

6 Nov 2008

Abstract excerpt

The death-associated protein kinase 1 (DAPK1) gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 gene has been found in many carcinomas. The epigenetic changes of TSGs are now recognized as a mechanism contributing to the development of chronic myeloid leukemia (CML). To clarify the role of DAPK1 in CML, we examined the methylation status of DAPK1 in 49 patients with CML using...

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PMID: 19018866
DOI: 10.1111/j.1600-0609.2008.01178.x

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