Article
A germ line mutation in the death domain of DAPK-1 inactivates ERK-induced apoptosis.
The Journal of biological chemistry - 4 May 2007
Stevens Craig, Lin Yao, Sanchez Maria, Amin Eliana, Copson Ellen, White Helen, Durston Vicky, Eccles Diana M, Hupp Ted
Abstract excerpt
p53 is activated genetically by a set of kinases that are components of the calcium calmodulin kinase superfamily, including CHK2, AMP kinase, and DAPK-1. In dissecting the mechanism of DAPK-1 control, a novel mutation (N1347S) was identified in the death domain of DAPK-1. The N1347S mutation prevented the death domain module binding stably to ERK in vitro and in vivo. Gel filtration demonstrated that the N1347S...
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