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Article

Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins.

Genetics - 1 Mar 2020

Hamza Akil, Driessen Maureen R M, Tammpere Erik, O'Neil Nigel J, Hieter Philip

Abstract excerpt

Cross-species complementation can be used to generate humanized yeast, which is a valuable resource with which to model and study human biology. Humanized yeast can be used as an in vivo platform to screen for chemical inhibition of human protein drug targets. To this end, we report the systematic complementation of nonessential yeast genes implicated in chromosome instability (CIN) with their human homologs. We...

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Identifiers

PMID: 31937519
DOI: 10.1534/genetics.119.302971
PMCID: PMC7054014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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