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Article

Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease.

Gut - 1 Feb 2014

Gutiérrez Ana, Scharl Michael, Sempere Laura, Holler Ernst, Zapater Pedro, Almenta Isabel, González-Navajas José M, Such José, Wiest Reiner, Rogler Gerhard, Francés Rubén

Abstract excerpt

OBJECTIVE: The aetiology of Crohn's disease (CD) has been related to nucleotide-binding oligomerisation domain containing 2 (NOD2) and ATG16L1 gene variants. The observation of bacterial DNA translocation in patients with CD led us to hypothesise that this process may be facilitated in patients w...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23376290
DOI: 10.1136/gutjnl-2012-303557

Genes

NOD2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23376290-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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