Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antimicrobial peptide response to blood translocation of bacterial DNA in Crohn's disease is affected by NOD2/CARD15 genotype.

Inflammatory bowel diseases - 1 Aug 2011

Gutiérrez Ana, Holler Ernst, Zapater Pedro, Sempere Laura, Jover Rodrigo, Pérez-Mateo Miguel, Schoelmerich Juergen, Such José, Wiest Reiner, Francés Rubén

Abstract excerpt

BACKGROUND: Blood translocation of bacterial-DNA has been described in patients with Crohn's disease (CD). The host's immune cell types cooperate to respond against bacterial insults. Some antimicrobial peptides are inducible after culture with bacterial products and a linkage has been established between them and NOD2/CARD15. The aim was to test whether defensins and cathelicidin (LL-37) expression and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Cationic Peptides
Share to beta-Defensins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cathelicidins

Share to Crohn Disease

Share to Interleukin-21

Share to Interleukins

Share to Neutrophils

Share to Nod2 Signaling Adaptor Protein

Source

Identifiers

PMID: 21744420
DOI: 10.1002/ibd.21537

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antimicrobial peptide response to blood translocation of bacterial DNA in Crohn's disease is affected by NOD2/CARD15 genotype.PMID 21744420Read ↗

Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease.Semantic proximity Read ↗

Lessons to be learned from the NOD2 gene in Crohn's disease.Semantic proximity Read ↗

Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing.Semantic proximity Read ↗

Analysis of the NOD2/CARD15 gene in patients affected with the aseptic abscesses syndrome with or without inflammatory bowel disease.Semantic proximity Read ↗

Abnormalities in the handling of intracellular bacteria in Crohn's disease: a link between infectious etiology and host genetic susceptibility.Semantic proximity Read ↗

NOD2/CARD15 mutations and presence of granulomas in pediatric and adult Crohn's disease.Semantic proximity Read ↗

Novel CARD15/NOD2 mutations in Finnish patients with Crohn's disease and their relation to phenotypic variation in vitro and in vivo.Semantic proximity Read ↗

NOD2/CARD15 gene polymorphisms in Crohn's disease: a genotype- phenotype analysis.Semantic proximity Read ↗

CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease.Semantic proximity Read ↗

NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes.Semantic proximity Read ↗

NOD2/CARD15 and TNFA, but not IL1B and IL1RN, are associated with Crohn's disease.Semantic proximity Read ↗

NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.