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Article

IL26 modulates cytokine response and anti-TNF consumption in Crohn's disease patients with bacterial DNA.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2017

Piñero Paula, Juanola Oriol, Gutiérrez Ana, Zapater Pedro, Giménez Paula, Steinert Anna, Sempere Laura, González-Navajas José M, Niess Jan H, Francés Rubén

Abstract excerpt

Interleukin IL26 supports killing of microbes and the innate sensing of bacterial-derived DNA (bactDNA). We evaluated the relationship between IL26 serum levels and bactDNA translocation in Crohn's disease (CD). We ran a prospective study on CD patients in remission. IL26 common polymorphisms, serum cytokines and complement protein, amplified-bactDNA, and anti-TNF-α were evaluated. In vitro PBMC analysis was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28879509
DOI: 10.1007/s00109-017-1585-6

Genes

TNF

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