Article
VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module.
Scientific reports - 27 Nov 2015
Oldenburg Joppe, van der Krogt Gerard, Twiss Floor, Bongaarts Annika, Habani Yasmin, Slotman Johan A, Houtsmuller Adriaan, Huveneers Stephan, de Rooij Johan
Abstract excerpt
Mechanical forces are integrated at cadherin-based adhesion complexes to regulate morphology and strength of cell-cell junctions and organization of associated F-actin. A central mechanosensor at the cadherin complex is α-catenin, whose stretching recruits vinculin to regulate adhesion strength. The identity of the F-actin regulating signals that are also activated by mechanical forces at cadherin-based junctions...
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