Article

Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP signaling pathway in the remodeling of blood vessels

2019-10-22

Abstract excerpt

<h4>Rationale</h4> The extracellular matrix (ECM) initiates mechanical cues and transduces intracellular signaling through matrix-cell interactions. In the blood vessels, additional mechanical cues derived from the pulsatile blood flow and pressure play a pivotal role in homeostasis and disease development. Currently, the nature of the cues from ECM and how they coordinate with a mechanical microenvironment in la...

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Literature Corpus work: a8d69ca8-e4c7-57ce-b263-9e3789e88ff9
DOI: 10.1101/814533

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