Article
Plasmodium falciparum sulfadoxine resistance is geographically and genetically clustered within the DR Congo.
Scientific reports - 1 Jan 2013
Taylor Steve M, Antonia Alejandro L, Parobek Christian M, Juliano Jonathan J, Janko Mark, Emch Michael, Alam Md Tauqeer, Udhayakumar Venkatachalam, Tshefu Antoinette K, Meshnick Steven R
Abstract excerpt
Understanding the spatial clustering of Plasmodium falciparum populations can assist efforts to contain drug-resistant parasites and maintain the efficacy of future drugs. We sequenced single nucleotide polymorphisms (SNPs) in the dihydropteroate synthase gene (dhps) associated with sulfadoxine resistance and 5 microsatellite loci flanking dhps in order to investigate the genetic backgrounds, genetic relatedness,...
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