Article
Global Analysis of Plasmodium falciparum Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study.
Molecules (Basel, Switzerland) - 24 Dec 2022
Boateng Rita Afriyie, Myers-Hansen James L, Dolling Nigel N O, Mensah Benedicta A, Brodsky Elia, Mazumder Mohit, Ghansah Anita
Abstract excerpt
The continual rise in sulfadoxine (SDX) resistance affects the therapeutic efficacy of sulfadoxine-pyrimethamine; therefore, careful monitoring will help guide its prolonged usage. Mutations in Plasmodium falciparum dihydropteroate synthase (Pfdhps) are being surveilled, based on their link with SDX resistance. However, there is a lack of continuous analyses and data on the potential effect of molecular markers...
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