Drug-Resistance and Population Structure of Plasmodium falciparum Across the Democratic Republic of Congo Using High-Throughput Molecular Inversion Probes.

doi:10.1093/infdis/jiy223

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Drug-Resistance and Population Structure of Plasmodium falciparum Across the Democratic Republic of Congo Using High-Throughput Molecular Inversion Probes.

The Journal of infectious diseases - 14 Aug 2018

Aydemir Ozkan, Janko Mark, Hathaway Nick J, Verity Robert, Mwandagalirwa Melchior Kashamuka, Tshefu Antoinette K, Tessema Sofonias K, Marsh Patrick W, Tran Alice, Reimonn Thomas, Ghani Azra C, Ghansah Anita, Juliano Jonathan J, Greenhouse Bryan R, Emch Michael, Meshnick Steven R, Bailey Jeffrey A

Abstract excerpt

A better understanding of the drivers of the spread of malaria parasites and drug resistance across space and time is needed. These drivers can be elucidated using genetic tools. Here, a novel molecular inversion probe (MIP) panel targeting all major drug-resistance mutations and a set of microsatellites was used to genotype Plasmodium falciparum infections of 552 children from the 2013-2014 Demographic and...

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PMID: 29718283
DOI: 10.1093/infdis/jiy223
PMCID: PMC6093412

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