The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis.

doi:10.1371/journal.pone.0054419

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Article

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis.

PloS one - 1 Jan 2013

Carmona F David, Martin Jose-Ezequiel, Beretta Lorenzo, Simeón Carmen P, Carreira Patricia E, Callejas José Luis, Fernández-Castro Mónica, Sáez-Comet Luis, Beltrán Emma, Camps María Teresa, Egurbide María Victoria, Airó Paolo, Scorza Raffaella, Lunardi Claudio, Hunzelmann Nicolas, Riemekasten Gabriela, Witte Torsten, Kreuter Alexander, Distler Jörg H W, Madhok Rajan, Shiels Paul, van Laar Jacob M, Fonseca Carmen, Denton Christopher, Herrick Ariane, Worthington Jane, Schuerwegh Annemie J, Vonk Madelon C, Voskuyl Alexandre E, Radstake Timothy R D J, Martín Javier

Abstract excerpt

Systemic sclerosis (SSc) is a fibrotic autoimmune disease in which the genetic component plays an important role. One of the strongest SSc association signals outside the human leukocyte antigen (HLA) region corresponds to interferon (IFN) regulatory factor 5 (IRF5), a major regulator of the type I IFN pathway. In this study we aimed to evaluate whether three different haplotypic blocks within this locus, which...

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Identifiers

PMID: 23372721
DOI: 10.1371/journal.pone.0054419
PMCID: PMC3553151

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