Phenotype-haplotype correlation of IRF5 in systemic sclerosis: role of 2 haplotypes in disease severity.

doi:10.3899/jrheum.091163

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Article

Phenotype-haplotype correlation of IRF5 in systemic sclerosis: role of 2 haplotypes in disease severity.

The Journal of rheumatology - 1 May 2010

Dieude Philippe, Dawidowicz Karen, Guedj Mickaël, Legrain Yona, Wipff Julien, Hachulla Eric, Diot Elisabeth, Sibilia Jean, Mouthon Luc, Cabane Jean, Amoura Zahir, Crakowski Jean-Luc, Carpentier Patrick, Avouac Jerome, Meyer Olivier, Kahan Andre, Boileau Catherine, Allanore Yannick

Abstract excerpt

OBJECTIVE: Identification of an association between IRF5 rs2004640 and systemic sclerosis (SSc) has highlighted a key role for type 1 interferon (IFN). Additional functional IRF5 variants have been identified as autoimmune susceptibility factors. Our aim was to investigate whether IRF5 haplotypes confer susceptibility to SSc, and to perform genotype haplotype-phenotype correlation analyses. METHODS: We genotyped...

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PMID: 20231204
DOI: 10.3899/jrheum.091163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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