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Article

STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis.

Arthritis and rheumatism - 1 Aug 2009

Dieudé P, Guedj M, Wipff J, Ruiz B, Hachulla E, Diot E, Granel B, Sibilia J, Tiev K, Mouthon L, Cracowski J L, Carpentier P H, Amoura Z, Fajardy I, Avouac J, Meyer O, Kahan A, Boileau C, Allanore Y

Abstract excerpt

OBJECTIVE: Systemic sclerosis (SSc) belongs to the group of connective tissue disorders (CTDs), among which are several disorders characterized by a type I interferon (IFN) signature. The recent identification of an association between IRF5 and SSc further highlights a key role for IFN. STAT4, wh...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19644887
DOI: 10.1002/art.24688

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19644887-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis.PMID 19644887Read ↗

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Defining genetic risk factors for scleroderma-associated interstitial lung disease : IRF5 and STAT4 gene variants are associated with scleroderma while STAT4 is protective against scleroderma-associated interstitial lung disease.Semantic proximity Read ↗

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Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosisSemantic proximity Read ↗

IRF5 polymorphism predicts prognosis in patients with systemic sclerosis.Semantic proximity Read ↗

The status of pulmonary fibrosis in systemic sclerosis is associated with IRF5, STAT4, IRAK1, and CTGF polymorphisms.Semantic proximity Read ↗

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis.Semantic proximity Read ↗

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Association of the IRF5 SNP rs2004640 with Systemic Sclerosis in Han ChineseSemantic proximity Read ↗

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk.Semantic proximity Read ↗

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