Article
IRF5 polymorphism predicts prognosis in patients with systemic sclerosis.
Annals of the rheumatic diseases - 1 Jul 2012
Sharif Roozbeh, Mayes Maureen D, Tan Filemon K, Gorlova Olga Y, Hummers Laura Kathleen, Shah Ami A, Furst Daniel E, Khanna Dinesh, Martin Javier, Bossini-Castillo Lara, Gonzalez Emilio B, Ying Jun, Draeger Hilda Torres, Agarwal Sandeep K, Reveille John D, Arnett Frank C, Wigley Fredrick M, Assassi Shervin
Abstract excerpt
OBJECTIVE: The first genome-wide association study (GWAS) of systemic sclerosis (SSc) demonstrated three non-major histocompatibility complex (MHC) susceptibility loci. The goal of this study was to investigate the impact of these gene variants on survival and severity of interstitial lung disease (ILD) in SSc. METHODS: The authors examined 1443 Caucasian SSc patients enrolled in the Genetics versus Environment...
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