Mapping genes that underlie ethnic differences in disease risk: methods for detecting linkage in admixed populations, by conditioning on parental admixture.

Abstract excerpt

Genes that underlie ethnic differences in disease risk can be mapped in affected individuals of mixed descent if the ancestry of the alleles at each marker locus can be assigned to one of the two founding populations. Linkage can be detected by testing for association of the disease with the ancestry of alleles at the marker locus, by conditioning on the admixture (defined as the proportion of genes that have...

Topics

• Alleles
• Chromosome Mapping
• Genetic Diseases, Inborn
• Genetic Linkage
• Genetic Markers
• Humans
• Markov Chains
• Models, Genetic
• Pedigree
• Polymorphism, Genetic
• Risk