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Article

Reduction of sample heterogeneity through use of population substructure: an example from a population of African American families with sarcoidosis.

American journal of human genetics - 1 Oct 2006

Thompson Cheryl L, Rybicki Benjamin A, Iannuzzi Michael C, Elston Robert C, Iyengar Sudha K, Gray-McGuire Courtney

Abstract excerpt

Sarcoidosis is a granulomatous inflammatory disorder of complex etiology with significant linkage to chromosome 5, and marginal linkage was observed to five other chromosomes in African Americans (AAs) in our previously published genome scan. Because genetic factors underlying complex disease are often population specific, genetic analysis of samples with diverse ancestry (i.e., ethnic confounding) can lead to...

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Identifiers

PMID: 16960797
DOI: 10.1086/507847
PMCID: PMC1592564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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