Article
A genome-wide admixture scan for ancestry-linked genes predisposing to sarcoidosis in African-Americans.
Genes and immunity - 1 Mar 2011
Rybicki B A, Levin A M, McKeigue P, Datta I, Gray-McGuire C, Colombo M, Reich D, Burke R R, Iannuzzi M C
Abstract excerpt
Genome-wide linkage and association studies have uncovered variants associated with sarcoidosis, a multiorgan granulomatous inflammatory disease. African ancestry may influence disease pathogenesis, as African-Americans are more commonly affected by sarcoidosis. Therefore, we conducted the first sarcoidosis genome-wide ancestry scan using a map of 1384 highly ancestry-informative single-nucleotide polymorphisms...
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