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Article

Admixture fine-mapping in African Americans implicates XAF1 as a possible sarcoidosis risk gene.

PloS one - 1 Jan 2014

Levin Albert M, Iannuzzi Michael C, Montgomery Courtney G, Trudeau Sheri, Datta Indrani, Adrianto Indra, Chitale Dhananjay A, McKeigue Paul, Rybicki Benjamin A

Abstract excerpt

Sarcoidosis is a complex, multi-organ granulomatous disease with a likely genetic component. West African ancestry confers a higher risk for sarcoidosis than European ancestry. Admixture mapping provides the most direct method to locate genes that underlie such ethnic variation in disease risk. We sought to identify genetic risk variants within four previously-identified ancestry-associated regions-6p24.3-p12.1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24663488
DOI: 10.1371/journal.pone.0092646
PMCID: PMC3963923

Genes

XAF1
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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