Article
A high-density admixture map for disease gene discovery in african americans.
American journal of human genetics - 1 May 2004
Smith Michael W, Patterson Nick, Lautenberger James A, Truelove Ann L, McDonald Gavin J, Waliszewska Alicja, Kessing Bailey D, Malasky Michael J, Scafe Charles, Le Ernest, De Jager Philip L, Mignault Andre A, Yi Zeng, De The Guy, Essex Myron, Sankale Jean-Louis, Moore Jason H, Poku Kwabena, Phair John P, Goedert James J, Vlahov David, Williams Scott M, Tishkoff Sarah A, Winkler Cheryl A, De La Vega Francisco M, Woodage Trevor, Sninsky John J, Hafler David A, Altshuler David, Gilbert Dennis A, O'Brien Stephen J, Reich David
Abstract excerpt
Admixture mapping (also known as "mapping by admixture linkage disequilibrium," or MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups such as African Americans, with approximately 100 times fewer markers than are required for whole-genome haplotype scans. However, it has not been possible to perform powerful scans with admixture mapping because the method requires a dense map of...
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