Article
Identification of uncommon PIK3CA mutations in lung cancer by using pyrosequencing.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 2013
Schildgen Verena, Lüsebrink Jessica, Appel Jan D, Wübben Christine, Engel-Riedel Walburga, Ludwig Corinna, Stoelben Erich, Schildgen Oliver, Brockmann Michael
Abstract excerpt
INTRODUCTION: Phospatidylinositol-3-kinases (PI3K) play an important role in various cell processes. Oncogenic mutations in the PIK3CA gene, which codes for the catalytic subunit, have been identified in various malignancies and activate the PI3K/AKT/mTOR pathway, which is a critical driver of tumorigenesis. METHODS: We tested 41 tumor samples with known KRAS, BRAF, and EGFR mutation status for the occurrence of...
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