PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, prognostic impact and incidence of prior malignancies.

doi:10.18632/oncotarget.2834

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Article

PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, prognostic impact and incidence of prior malignancies.

Oncotarget - 20 Jan 2015

Scheffler Matthias, Bos Marc, Gardizi Masyar, König Katharina, Michels Sebastian, Fassunke Jana, Heydt Carina, Künstlinger Helen, Ihle Michaela, Ueckeroth Frank, Albus Kerstin, Serke Monika, Gerigk Ulrich, Schulte Wolfgang, Töpelt Karin, Nogova Lucia, Zander Thomas, Engel-Riedel Walburga, Stoelben Erich, Ko Yon-Dschun, Randerath Winfried, Kaminsky Britta, Panse Jens, Becker Carolin, Hellmich Martin, Merkelbach-Bruse Sabine, Heukamp Lukas C, Büttner Reinhard, Wolf Jürgen

Abstract excerpt

BACKGROUND: Somatic mutations of the PIK3CA gene have been described in non-small cell lung cancer (NSCLC), but limited data is available on their biological relevance. This study was performed to characterize PIK3CA-mutated NSCLC clinically and genetically. PATIENTS AND METHODS: Tumor tissue collected consecutively from 1144 NSCLC patients within a molecular screening network between March 2010 and March 2012...

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PMID: 25473901
DOI: 10.18632/oncotarget.2834
PMCID: PMC4359235

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EGFR

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