Article
Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review.
BMC cancer - 7 Jul 2016
Harada Kazuto, Baba Yoshifumi, Shigaki Hironobu, Ishimoto Takatsugu, Miyake Keisuke, Kosumi Keisuke, Tokunaga Ryuma, Izumi Daisuke, Ohuchi Mayuko, Nakamura Kenichi, Kiyozumi Yuki, Kurashige Junji, Iwatsuki Masaaki, Miyamoto Yuji, Sakamoto Yasuo, Yoshida Naoya, Watanabe Masayuki, Baba Hideo
Abstract excerpt
BACKGROUND: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) mutations that activate the PI3K/AKT signaling pathway have been observed in several types of carcinoma and have been associated with patient prognosis. However, the significance of PIK3CA mutations in gastric cancer remains unclear. This retrospective study investigated the relationship between PIK3CA mutations and...
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