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Article

Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling.

Molecular cancer therapeutics - 1 Feb 2012

Chaft Jamie E, Arcila Maria E, Paik Paul K, Lau Christopher, Riely Gregory J, Pietanza M Catherine, Zakowski Maureen F, Rusch Valerie, Sima Camelia S, Ladanyi Marc, Kris Mark G

Abstract excerpt

Phosphoinositide-3-kinase catalytic alpha polypeptide (PIK3CA) encodes the p110α subunit of the mitogenic signaling protein phosphoinositide 3-kinase (PI3K). PIK3CA mutations in the helical binding domain and the catalytic subunit of the protein have been associated with tumorigenesis and treatment resistance in various malignancies. Characteristics of patients with PIK3CA-mutant lung adenocarcinomas have not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22135231
DOI: 10.1158/1535-7163.MCT-11-0692
PMCID: PMC3593239

Genes

ALK
EGFR
KRAS
BRAF
AKT1
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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