Article
KRAS, BRAF, and PIK3CA mutations, and patient prognosis in 126 pancreatic cancers: pyrosequencing technology and literature review.
Medical oncology (Northwood, London, England) - 1 Apr 2016
Zhou Lei, Baba Yoshifumi, Kitano Yuki, Miyake Keisuke, Zhang Xiaobo, Yamamura Kensuke, Kosumi Keisuke, Kaida Takayoshi, Arima Kota, Taki Katsunobu, Higashi Takaaki, Imai Katsunori, Hashimoto Daisuke, Yamashita Yoichi, Chikamoto Akira, Beppu Toru, Tan Xiaodong, Baba Hideo
Abstract excerpt
The oncogenic hallmarks of pancreatic cancer (PC), such as the KRAS, BRAF, and PIK3CA mutations, have been widely investigated. However, almost all of the previous studies were limited by small sample sizes. In addition, previous data on the KRAS mutation and clinical outcomes in PC remain inconclusive. To clarify these data, we examined the mutation status of 126 PC patients and its relationship to clinical...
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