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Article

RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function.

Genes & development - 15 Aug 2011

Moshkovich Nellie, Nisha Parul, Boyle Patrick J, Thompson Brandi A, Dale Ryan K, Lei Elissa P

Abstract excerpt

A major role of the RNAi pathway in Schizosaccharomyces pombe is to nucleate heterochromatin, but it remains unclear whether this mechanism is conserved. To address this question in Drosophila, we performed genome-wide localization of Argonaute2 (AGO2) by chromatin immunoprecipitation (ChIP)-seq in two different embryonic cell lines and found that AGO2 localizes to euchromatin but not heterochromatin. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fluorescent Antibody Technique, Indirect

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Source

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Identifiers

PMID: 21852534
DOI: 10.1101/gad.16651211
PMCID: PMC3165934

Genes

AGO2
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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