Article
The major transcriptional transactivation domain of simian virus 40 large T antigen associates nonconcurrently with multiple components of the transcriptional preinitiation complex.
Journal of virology - 1 Feb 1996
Johnston S D, Yu X M, Mertz J E
Abstract excerpt
Simian virus 40 (SV40) large T antigen (Tag) is a promiscuous transcriptional transactivator; however, its mechanism of transactivation remains unknown. Recent studies have suggested the possible involvement of protein-protein interactions with TBP, the TATA box-binding protein of TFIID, and TEF-...
Topics
- Antigens, Polyomavirus Transforming
- Binding Sites
- HeLa Cells
- Humans
- Mutation
- Protein Binding
- RNA Polymerase II
- Simian virus 40
- Sp1 Transcription Factor
- Structure-Activity Relationship
- Transcription Factor TFIIB
- Transcription Factor TFIID
- Transcription Factors
- Transcriptional Activation