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Article

Herpes simplex virus infections are arrested in Oct-1-deficient cells

26 Jan 2004

Abstract excerpt

Expression of the herpes simplex virus (HSV) immediate early (IE) genes is regulated by a multiprotein complex that is assembled on the TAATGARAT enhancer core element. The complex contains the cellular POU domain protein Oct-1, the viral transactivator VP16, and the cellular cofactor host cell factor 1. The current model suggests that the assembly depends on recognition of the core element by Oct-1. Here, HSV...

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Identifiers

PMID: 14745036
DOI: 10.1073/pnas.0307300101

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Source receipt: pubmed, retrieved 7 Sept 2026.

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