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Article

Manganese efflux in Parkinsonism: insights from newly characterized SLC30A10 mutations.

Biochemical and biophysical research communications - 1 Mar 2013

DeWitt Margaret R, Chen Pan, Aschner Michael

Abstract excerpt

Although manganese (Mn) is required for normal cellular function, overexposure to this metal may cause an extrapyramidal syndrome resembling Parkinson's disease (PD). Notably, high whole-blood Mn levels have been reported in patients with idiopathic PD. Because Mn is both essential at low dose and toxic at higher dose; its transport and homeostasis are tightly regulated. Previously, the only protein known to be...

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Identifiers

PMID: 23357421
DOI: 10.1016/j.bbrc.2013.01.058
PMCID: PMC3594538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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