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Article

Familial manganese-induced neurotoxicity due to mutations in SLC30A10 or SLC39A14.

Neurotoxicology - 1 Jan 2018

Mukhopadhyay Somshuvra

Abstract excerpt

Over the last few years, two rare, familial diseases that lead to the onset of manganese (Mn)-induced neurotoxicity have been discovered. Loss-of-function mutations in SLC30A10, a Mn efflux transporter, or SLC39A14, a Mn influx transporter, increase Mn levels in blood and brain, and induce severe neurotoxicity. The discoveries of these genetic diseases have transformed our understanding of Mn homeostasis,...

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Identifiers

PMID: 28789954
DOI: 10.1016/j.neuro.2017.07.030
PMCID: PMC5799044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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